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In addition, NCOA4-mediated ferritin degradation, also known as ferritinophagy, increases the intracellular iron ion levels, promotes lipid peroxidation, and triggers ferroptosis ( Figure 2 Ferroptosis has emerged as a promising target for cancer therapy ( Natural products targeting the iron death signaling pathway affect tumor growth Based on the characteristics of the ferroptosis signaling pathway, natural products that can induce ferroptosis mainly include the following types: 1

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Thank you Matthew